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2-fold respectively) with no statistically significant effects on the blood glucose levels In a double-blind, placebo-controlled, 3-month dose titration study, PRANDIN or placebo doses for each patient were increased weekly from 0. The maximum recommended daily dose is 16 mg. 5 mg PO before each meal HbA1c ≥8%: 1-2 mg PO before each meal; Dosage range. 5, 1, and 2 mg, to a maximum of 4 mg, until a fasting plasma glucose (FPG) level. 5 to 4 mg orally with each meal Maximum Daily Dose: 16 mg per day Comments:. Repaglinide was not teratogenic in rats or rabbits during organogenesis at doses 60 and 1 times the maximum daily clinical dose, based on body surface area. 25 mg) increased the repaglinide AUC, C max and t ½ (1. The recommended dose range is 0. Double dose up to 4 mg with each meal until satisfactory glycemic control achieved; Wait at least 1 week to assess response after each. 5-4 mg before meals; Maximum daily dose: Not to exceed 16 mg/day; Dosage adjustment. PRANDIN may be dosed preprandially 2, 3, or 4 times a day in response to changes in the patient’s meal pattern.

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